Cannabidiol (CBD) is available in many forms, including oils, tablets and creams. The ideal dosages vary depending on its shape and use. However, there is little research, so doctors are not yet able to confirm the safe and beneficial dosages for each use.
CBD is an active ingredient in the cannabis plant. Products containing CBD can have certain health benefits, but they can also pose risks.
The CBD market is growing at a rapid rate and the research corpus is growing. However, there is still confusion about the laws, the use of CBD, its safety and its effectiveness.
CBD products are legal, although their legal status varies by state. The Food and Drug Administration (FDA) does not control most CBD products. As a result, the quality, amount of CBD per dose, and product safety can vary widely, and it is difficult to calculate an optimal dosage.
This article examines CBD dosages, including research on dosages that are safe and effective, as well as the possible risks of using CBD products.
To date, the FDA has approved only one cannabis-derived product called Epidiolex, and it is only available by prescription. This approval covers the treatment of seizures in people with severe epilepsy called Lennox-Gastaut syndrome and Dravet syndrome.
The dosage of Epidiolex, a form of CBD oil, is as follows:
- The starting dose is 2.5 milligrams per kilogram body weight (mg/kg) twice daily, for a total dosage of 5 mg/kg per day.
- After 1 week, people can increase the dosage to 5 mg/kg twice a day, for a total of 10 mg/kg per day.
All other CBD-containing products do not fall under FDA regulations, so there are no official guidelines for their dosage. Some manufacturers advertise products to CBD with unproven medical claims, and the quality and safety of these products may vary.
Before using any other CBD product, a person should speak to their doctor about the proper dosages.
The dosage a person takes will depend on the mode of administration they use and the specific product. Modes of administration include:
- CBD oil solutions
- CBD capsules
- tablets that a person places under the tongue (sublingual)
- nasal sprays
Recently, a wider range of products containing CBD has become available. These elements understand food products, food supplements, cosmetics, and animal health products.
Research on CBD therapy is still in its infancy, and scientists need to do much more research to determine the benefits and risks of CBD products. Above all, researchers must find the ideal CBD dosages that are both safe and effective for each condition.
As a therapy, CBD oil has gained a high level of interest in research. AT Medical news today, we have covered what research to date has shown about the role of CBD under the following conditions:
According to a World Health Organization (WHO) report, research has suggested that CBD oil may also have therapeutic benefits for the following conditions:
Since the FDA has only approved the use of CBD for specific forms of epilepsy, doctors know little about the dose that people should take when using it for other reasons. As with any drug, the appropriate dosage is one that provides a therapeutic effect and is well tolerated.
In clinical studies, researchers have used various oral doses of CBD, ranging from 100–800 mg per day.
Some studies use even higher doses. According to a review, one person reported an improvement in psychosis after taking 1,200 mg daily for a few weeks. In another study, people with schizophrenia reported benefits after taking increasing doses of 40 to 1,280 mg daily for 4 weeks.
In one study on the effects of CBD in people with Parkinson’s disease and psychosis, six participants showed significant improvement in symptoms with a dose of 150 mg per day of CBD.
The following table lists the method of administration and the dosage of CBD that the researchers used to study its therapeutic effects on different medical conditions.
To find out if a CBD product is safe and to determine the effective dosage, people should consult a doctor.
Several factors can influence the dosage people can take. Depending on the medical condition or the reason a person is taking CBD, they will need a different dose.
Some people need high doses to control epilepsy, while smaller doses may be effective against anxiety.
Another factor that people should consider before using CBD is their weight. In many clinical trials and when using Epidiolex, doctors calculate a dose per kg of body weight. People who weigh less should, therefore, take lower doses than people who weigh more.
Alcohol and other central nervous system depressants can increase the sedative effect of CBD. People who use other drugs that can cause drowsiness should avoid or reduce their dose of CBD. Before mixing alcohol and other drugs with CBD, a person should ask their doctor if they are safe.
People should also consider the dosage of each form of CBD. A CBD capsule has a specific dosage, but the dosage of oral solutions depends on the volume. For example, a CBD solution containing 25 mg per milliliter (ml) can provide 125 mg if a person takes a full teaspoon, which equals 5 ml.
Although data in humans remain limited regarding the effects of taking pure CBD, the researchers suggest that it has relatively low toxicity.
In monkeys, CBD does not affect bodily functions or behavior, unless the animals receive doses greater than 30 mg/kg orally daily for 90 days or 150 mg/kg intravenously.
In a study on human physical dependence, researchers gave people 1500 mg daily of CBD for 4 weeks. Study participants were not withdrawn after the 28-day trial. Another study found that doses up to 1500 mg daily were well tolerated.
the World Health Organization (WHO) also report that people generally tolerate CBD well. CBD does not cause a “high” and it does not have the same potential for abuse as cannabis.
CBD safety data is limited. The available data indicates the possible risks that people should consider before taking CBD for any reason.
Some Side effects CBD are visible, including:
- drowsiness or other changes in alertness
- digestive problems, such as diarrhea and decreased appetite
- mood changes, such as irritability and restlessness
Other side effects may occur without people being aware of them, such as:
- Hepatic insufficiency
- interactions with other drugs
- injuries from mixing alcohol or other depressants and CBD
Several factors determine the dose of CBD a person can take, including the intended use and the person’s weight. Although the evidence is still lacking, researchers have identified certain drugs that interact with CBD, which can also affect the dosage that a person can tolerate.
The FDA has approved only one CBD product. Research on the possible uses, dosages, benefits and safety of CBD is underway.